15th–16th March 2023
13:30-18:30h CET

Epithelioid Sarcoma Digital Expert Panel 2023

Welcome to the second Epithelioid Sarcoma Digital Expert Panel that will take place on March 15-16th 2023. The translational conference will be the continuation of the digital expert meeting that was successfully held in 2021 and will be moderated by Prof. Dr. Dr. Thomas Grünewald, Head of the Division for Translational Pediatric Sarcoma Research at the German Cancer Research Center (DKFZ) and Hopp Children's Cancer Center (KiTZ) Heidelberg, and by Dr. Sandro Pasquali, Clinician Scientist at the Sarcoma Service and the Molecular Pharmacology of Fondazione IRCCS Istituto Nazionale dei Tumori in Milano.

The meeting is meant for experts in sarcoma research, treating clinicians and scientists from related disciplines. It provides a forum for the exchange and discussion of current research aspects including new therapeutic approaches around epithelioid sarcoma. The event promotes networking and discussion among experts and lays the foundation for future international collaborations.

We are looking forward to see you at the panel in March. 

Kind regards

Dr. Michael Wortmann Andrea Bolzicco
SMARCB1 e.V. Orchestra per la Vita Aps

Dr. Michael Wortmann,  michael.wortmann@smarcb1.de , https://www.smarcb1.de
SMARCB1 e.V. Cancer Research for young people | Forschpfad 6, 51427 Bergisch Gladbach, Germany

Andrea Bolzicco, andrea.bolzicco@orchestraperlavita.org, https://www.orchestraperlavita.org
Orchestra per la vita Aps | Via Canada, 15 – 00060 Formello (Rome),  Italy

We thank the new organization “MC4 in corsa per la vita !” ETS (Italy) for supporting the event.

Panel Speaker

Prof. Dr. Dr. Thomas Grünewald

Head of Division for Translational Pediatric Sarcoma Research, the German Cancer Research Center (DKFZ) and Hopp Children's Cancer Center (KiTZ) Heidelberg

Dr. Sandro Pasquali


Clinician Scientist, Sarcoma Service and the Molecular Pharmacology, Fondazione IRCCS Istituto Nazionale dei Tumori in Milano

Prof. Dr. Vincenzo Cerullo

Head of Immunovirotherapy Lab, Division of Pharmaceutical Biosciences, University of Helsinki

Dr. Paul Huang


Molecular and Systems Oncology, Division of Molecular Pathology, Institute of Cancer Research, London

Cigall Kadoch, PhD

Associate Professor of Pedriatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School

Charles Keller, MD

Scientific Director, Children's Cancer Therapy Development Institute

Dr. Noemi Arrighetti, PhD

Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori

PD Dr. med Pascal Johann

Experimental Oncology and Tumor Epigenetics, University Hospital Augsburg 

Prof. Alberto Danielli

Associate Professor Molecular Biology, Department of Pharmacy and Biotechnology, University of Bologna

Cristina R. Antonescu, MD

Director, Bone and Soft Tissue Pathology, Memorial Sloan Kettering Cancer Center 

Prof. Anna M. Czarnecka

Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology in Warsaw

Prof. Maria Rescigno

Deputy Rector with responsibility for research and Group Leader Mucosal immunology and microbiota Unit, Humanitas Research Hospital

Dr. Vittoria Matafora

Staff Scientist at IFOM Proteomics Lab, the FIRC Institute for Molecular Oncology, Milan

Prof. Dario Sangiolo

Associate Professor at the Department of Oncology, University of Turin

Dr. Marco Gambarotti

Head of the structure "Anatomy and pathological histology" - Istituto Ortopedico Rizzoli, Bologna

Dr. Luca Sigalotti

Chief Biologist - Centro di Riferimento Oncologico, Aviano 

Sophie Postel-Vinay, MD, PhD, HDR

Physician Scientist, Drug Development Department and U981 INSERM research unit,  Gustave Roussy Cancer Campus

Andrea Bolzicco

Associazione Orchestra per la Vita - APS

Dr. Michael Wortmann

SMARCB1 e.V. - Cancer Research for young People

 

Agenda Day 1 (15.03.2023)

13:30 CET Berlin
08:30 am ET Boston

Welcome and Introduction

Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany, Sandro Pasquali, Surgeon and Clinician Scientist at the Sarcoma Service at the Istituto Nazionale Tumori, Milan, Italy, Michael Wortmann, SMARCB1 e.V., Germany and Andrea Bolzicco, Orchestra per la Vita, Italy.

14:00 CET Berlin
09:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Sandro Pasquali)

Exploring tumor heterogeneity in Epithelioid Sarcoma
Sophie Postel-Vinay, Gustave Roussy Cancer Campus, Villejuif, France

Translational and functional genomics of Epithelioid sarcoma
Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research
Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany

14:45 CET Berlin
09:45 am ET Boston

Break and online network

15:00 CET Berlin
10:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

Proteomic characterisation of SMARCB1-deficient cancers
Paul Huang, The Institute of Cancer Research, United Kingdom

Proteomic analysis of epithelioid sarcoma
Vittoria Matafora, IFOM -Istituto FIRC di Oncologia Molecolare, Milan, Italy

15:45 CET Berlin
10:45 am ET Boston

Break and online network

16:00 CET Berlin
11:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

Multi-omics profiling of epithelioid sarcoma unveils biologic differences of proximal and classic variant
Luca Sigalotti, CRO Centro di Riferimento Oncologico, Aviano, Italy

Epigenetic vulnerabilities of epithelioid sarcomas - a comparative analysis with other SMARCB1 deficient entities
Pascal Johann, Peadiatric Oncology and Paediatric Haematology, University Augsburg, Germany

16:45 CET Berlin
11:45 am ET Boston

Break and online network

17:00 CET Berlin
12:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms
Cristina R. Antonescu, Memorial Sloan Kettering Cancer Center New York, USA

RIZZOLI Muscolo-Skeletal tumor BIOBANK- Epithelioid sarcoma’s resources.
Marco Gambarotti, Istituto Ortopedico Rizzoli, Biologic Resources Center,  Bologna, Italy

17:45 CET Berlin
12:45 pm ET Boston

Break and online network

18:00 CET Berlin
13:00 pm ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in SMARCB1-Deficient Malignancies
Cigall Cadoch, Kadoch LAB, Dana-Farber Cancer Institute, Harvard Medical School, USA

18:30 CET Berlin
13:30 pm ET Boston

End of Day 1

Agenda Day 2 (16.03.2023)

13:30 CET Berlin
08:30 am ET Boston

Welcome and Introduction

Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany, Sandro Pasquali, Surgeon and Clinician Scientist at the Sarcoma Service at the Istituto Nazionale Tumori, Milan, Italy, Michael Wortmann, SMARCB1 e.V., Germany and Andrea Bolzicco, Orchestra per la Vita, Italy.

14:00 CET Berlin
09:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Sandro Pasquali)

Antitumor activity of tazemetostat and doxorubicin combination: different outcomes in two epithelioid sarcoma models
Noemi Arrighetti, Istituto Nazionale dei Tumori, Milan, Italy

Long-term results of epithelioid sarcoma multidisciplinary treatment in reference sarcoma center
Anna Czarnecka, Maria Sklodowska-Curie National Research Institute of Oncology, Poland

14:45 CET Berlin
09:45 am ET Boston

Break and online network

15:00 CET Berlin
10:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

Soft-tissue sarcoma microbiota and immunology
Maria Rescigno, Humanitas Research University, Milan, Italy

Immunotherapy with CAR redirected cytokine-Induced Killer lymphocytes as explorative approach against Epithelioid Sarcoma
Dario Sangiolo, University of Torino, Italy

15:45 CET Berlin
10:45 am ET Boston

Break and online network

16:00 CET Berlin
11:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

Personalized cancer vaccine for epitheliod sarcoma
Vincenzo Cerullo, University of Helsinki, Finland

Nanobiotechnological engineering the M13 phage for targeted photosonodynamic therapy of Epitheliod Sarcoma
Alberto Danielli, FaBiT - Department of Pharmacy & Biotechnology, University of Bologna, Italy

16:45 CET Berlin
11:45 am ET Boston

Break and online network

17:00 CET Berlin
12:00 am ET Boston

Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)

Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology
Charles Keller, Children’s Cancer Therapy Development Institute, USA

17:20 CET Berlin
12:20 pm ET Boston

Conclusion Remarks 

Thomas Grünewald & Sandro Pasquali


17:50 CET Berlin
12:50 pm ET Boston

End of Day 2


Technical information


Digital conference

The Epithelioid Sarcoma Digital Expert Panel is a digital event and will be hostet online. Once you have registered as a participant, you will receive more information and a link via email to dial-in on both days of the event.


Technical Questions

For technical questions please contact us by email: info@smarcb1.de or by phone +49 176 636 555 23