15th–16th March 2023
13:30-18:30h CET
Epithelioid Sarcoma Digital Expert Panel 2023
Welcome to the second Epithelioid Sarcoma Digital Expert Panel that will take place on March 15-16th 2023. The translational conference will be the continuation of the digital expert meeting that was successfully held in 2021 and will be moderated by Prof. Dr. Dr. Thomas Grünewald, Head of the Division for Translational Pediatric Sarcoma Research at the German Cancer Research Center (DKFZ) and Hopp Children's Cancer Center (KiTZ) Heidelberg, and by Dr. Sandro Pasquali, Clinician Scientist at the Sarcoma Service and the Molecular Pharmacology of Fondazione IRCCS Istituto Nazionale dei Tumori in Milano.
The meeting is meant for experts in sarcoma research, treating clinicians and scientists from related disciplines. It provides a forum for the exchange and discussion of current research aspects including new therapeutic approaches around epithelioid sarcoma. The event promotes networking and discussion among experts and lays the foundation for future international collaborations.
We are looking forward to see you at the panel in March.
Kind regards
Dr. Michael Wortmann Andrea Bolzicco
SMARCB1 e.V. Orchestra per la Vita Aps
Dr. Michael Wortmann, michael.wortmann@smarcb1.de , https://www.smarcb1.de
SMARCB1 e.V. Cancer Research for young people | Forschpfad 6, 51427 Bergisch Gladbach, Germany
Andrea Bolzicco, andrea.bolzicco@orchestraperlavita.org, https://www.orchestraperlavita.org
Orchestra per la vita Aps | Via Canada, 15 – 00060 Formello (Rome), Italy
We thank the new organization “MC4 in corsa per la vita !” ETS (Italy) for supporting the event.
Panel Speaker
Prof. Dr. Dr. Thomas Grünewald
Head of Division for Translational Pediatric Sarcoma Research, the German Cancer Research Center (DKFZ) and Hopp Children's Cancer Center (KiTZ) Heidelberg
Dr. Sandro Pasquali
Clinician Scientist, Sarcoma Service and the Molecular Pharmacology, Fondazione IRCCS Istituto Nazionale dei Tumori in Milano
Prof. Dr. Vincenzo Cerullo
Head of Immunovirotherapy Lab, Division of Pharmaceutical Biosciences, University of Helsinki
Dr. Paul Huang
Molecular and Systems Oncology, Division of Molecular Pathology, Institute of Cancer Research, London
Cigall Kadoch, PhD
Associate Professor of Pedriatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School
Charles Keller, MD
Scientific Director, Children's Cancer Therapy Development Institute
Dr. Noemi Arrighetti, PhD
Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori
PD Dr. med Pascal Johann
Experimental Oncology and Tumor Epigenetics, University Hospital Augsburg
Prof. Alberto Danielli
Associate Professor Molecular Biology, Department of Pharmacy and Biotechnology, University of Bologna
Cristina R. Antonescu, MD
Director, Bone and Soft Tissue Pathology, Memorial Sloan Kettering Cancer Center
Prof. Anna M. Czarnecka
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology in Warsaw
Prof. Maria Rescigno
Deputy Rector with responsibility for research and Group Leader Mucosal immunology and microbiota Unit, Humanitas Research Hospital
Dr. Vittoria Matafora
Staff Scientist at IFOM Proteomics Lab, the FIRC Institute for Molecular Oncology, Milan
Prof. Dario Sangiolo
Associate Professor at the Department of Oncology, University of Turin
Dr. Marco Gambarotti
Head of the structure "Anatomy and pathological histology" - Istituto Ortopedico Rizzoli, Bologna
Dr. Luca Sigalotti
Chief Biologist - Centro di Riferimento Oncologico, Aviano
Sophie Postel-Vinay, MD, PhD, HDR
Physician Scientist, Drug Development Department and U981 INSERM research unit, Gustave Roussy Cancer Campus
Andrea Bolzicco
Associazione Orchestra per la Vita - APS
Dr. Michael Wortmann
SMARCB1 e.V. - Cancer Research for young People
Agenda Day 1 (15.03.2023)
13:30 CET Berlin
08:30 am ET Boston
Welcome and Introduction
Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany, Sandro Pasquali, Surgeon and Clinician Scientist at the Sarcoma Service at the Istituto Nazionale Tumori, Milan, Italy, Michael Wortmann, SMARCB1 e.V., Germany and Andrea Bolzicco, Orchestra per la Vita, Italy.
14:00 CET Berlin
09:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Sandro Pasquali)
Exploring tumor heterogeneity in Epithelioid Sarcoma
Sophie Postel-Vinay, Gustave Roussy Cancer Campus, Villejuif, France
Translational and functional genomics of Epithelioid sarcoma
Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research
Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany
14:45 CET Berlin
09:45 am ET Boston
Break and online network
15:00 CET Berlin
10:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
Proteomic characterisation of SMARCB1-deficient cancers
Paul Huang, The Institute of Cancer Research, United Kingdom
Proteomic analysis of epithelioid sarcoma
Vittoria Matafora, IFOM -Istituto FIRC di Oncologia Molecolare, Milan, Italy
15:45 CET Berlin
10:45 am ET Boston
Break and online network
16:00 CET Berlin
11:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
Multi-omics profiling of epithelioid sarcoma unveils biologic differences of proximal and classic variant
Luca Sigalotti, CRO Centro di Riferimento Oncologico, Aviano, Italy
Epigenetic vulnerabilities of epithelioid sarcomas - a comparative analysis with other SMARCB1 deficient entities
Pascal Johann, Peadiatric Oncology and Paediatric Haematology, University Augsburg, Germany
16:45 CET Berlin
11:45 am ET Boston
Break and online network
17:00 CET Berlin
12:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms
Cristina R. Antonescu, Memorial Sloan Kettering Cancer Center New York, USA
RIZZOLI Muscolo-Skeletal tumor BIOBANK- Epithelioid sarcoma’s resources.
Marco Gambarotti, Istituto Ortopedico Rizzoli, Biologic Resources Center, Bologna, Italy
17:45 CET Berlin
12:45 pm ET Boston
Break and online network
18:00 CET Berlin
13:00 pm ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in SMARCB1-Deficient Malignancies
Cigall Cadoch, Kadoch LAB, Dana-Farber Cancer Institute, Harvard Medical School, USA
18:30 CET Berlin
13:30 pm ET Boston
End of Day 1
Agenda Day 2 (16.03.2023)
13:30 CET Berlin
08:30 am ET Boston
Welcome and Introduction
Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany, Sandro Pasquali, Surgeon and Clinician Scientist at the Sarcoma Service at the Istituto Nazionale Tumori, Milan, Italy, Michael Wortmann, SMARCB1 e.V., Germany and Andrea Bolzicco, Orchestra per la Vita, Italy.
14:00 CET Berlin
09:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Sandro Pasquali)
Antitumor activity of tazemetostat and doxorubicin combination: different outcomes in two epithelioid sarcoma models
Noemi Arrighetti, Istituto Nazionale dei Tumori, Milan, Italy
Long-term results of epithelioid sarcoma multidisciplinary treatment in reference sarcoma center
Anna Czarnecka, Maria Sklodowska-Curie National Research Institute of Oncology, Poland
14:45 CET Berlin
09:45 am ET Boston
Break and online network
15:00 CET Berlin
10:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
Soft-tissue sarcoma microbiota and immunology
Maria Rescigno, Humanitas Research University, Milan, Italy
Immunotherapy with CAR redirected cytokine-Induced Killer lymphocytes as explorative approach against Epithelioid Sarcoma
Dario Sangiolo, University of Torino, Italy
15:45 CET Berlin
10:45 am ET Boston
Break and online network
16:00 CET Berlin
11:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
Personalized cancer vaccine for epitheliod sarcoma
Vincenzo Cerullo, University of Helsinki, Finland
Nanobiotechnological engineering the M13 phage for targeted photosonodynamic therapy of Epitheliod Sarcoma
Alberto Danielli, FaBiT - Department of Pharmacy & Biotechnology, University of Bologna, Italy
16:45 CET Berlin
11:45 am ET Boston
Break and online network
17:00 CET Berlin
12:00 am ET Boston
Presentations (10-15 min.) & Discussion (10-15 min.). (Moderator Thomas Grünewald)
Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology
Charles Keller, Children’s Cancer Therapy Development Institute, USA
17:20 CET Berlin
12:20 pm ET Boston
Conclusion Remarks
Thomas Grünewald & Sandro Pasquali
17:50 CET Berlin
12:50 pm ET Boston
End of Day 2
Technical information
Digital conference
The Epithelioid Sarcoma Digital Expert Panel is a digital event and will be hostet online. Once you have registered as a participant, you will receive more information and a link via email to dial-in on both days of the event.
Technical Questions
For technical questions please contact us by email: info@smarcb1.de or by phone +49 176 636 555 23